DESCRIPTION:
Two compartments TMDD model assuming doses injected directly into central compartment


[LONGITUDINAL]
input = {Cll, kep, kon, kout, koff, Vc, R0, Vt, Cld}

PK:

depot(target=L)  

EQUATION:
kin   = kout*R0 ; Synthesis of receptor
kel = Cll/Vc
k21 = Cld/Vt
k12 = Cld/Vc

;Initial Conditions
R_0 = R0
P_0 = 0

;Ordinary Differential Equations
ddt_L = -kel*L-kon*L*R+koff*P - k12*L + k21*D 
;ddt_L = -kel*L-kon*L*R+koff*P 
ddt_D =  k12*L - k21*D 
ddt_R = kin-kout*R-kon*L*R+koff*P
ddt_P = kon*L*R-koff*P-kep*P

C = L/Vc